Overview   

Gastritis refers to the inflammation of the stomach lining, known as the mucosa, which protect the stomach from the daily exposure to acids, enzymes, and microorganisms. This inflammation is commonly triggered by an infection from the same bacterium that causes many stomach ulcers, or by the regular usage of specific pain relievers. Excessive alcohol consumption can also contribute to the development of gastritis.  

There are two main types of gastritis: acute and chronic. 

  • Acute gastritis: Occurs suddenly and is of a temporary nature. The factors leading to its occurrence are typically acute as well. 
  • Chronic gastritis: Is a persistent condition that often develops gradually, usually as a result of an underlying chronic health issue. While you may not always notice its presence, it can persist over the long term. 

Gastritis can further be categorized into erosive and nonerosive forms. 

  • Erosive gastritis: Involves substances that actively damage the stomach lining, leading to the formation of ulcers. These damaging agents can include chemicals like acid, bile, alcohol, or certain medications. 
  • Nonerosive gastritis: Doesn’t lead to ulcers but can still cause irritation, resulting in the reddening of the stomach lining. Atrophic gastritis, a specific form of nonerosive gastritis, can cause the thinning or wasting away (atrophy) of the stomach lining, leading to potential digestive problems. 

Gastritis can potentially result in ulcers and an increased risk of stomach cancer. Nevertheless, for most cases, gastritis is not a severe condition and typically responds well to treatment, improving rapidly. 

Symptoms   

Gastritis can sometimes be without symptoms. However, if symptoms do occur, they could suggest a more severe or prolonged condition. Symptoms might emerge when the stomach lining becomes worn down, unable to protect against its own acids and enzymes. These acids can cause indigestion or even the formation of stomach ulcers, which can be painful and lead to bleeding. Common symptoms include:  

  • Reduced appetite or feeling full shortly after a meal. 
  • Stomach discomfort and a sense of fullness. 
  • Nausea and/or vomiting. 

In the case of a bleeding ulcer, you might notice: 

  • Dark, tarlike stool (melena). 
  • Vomit resembling coffee grounds in color and texture. 

Seek medical attention immediately if you have:  

  • Severe pain.  
  • Inability to keep food down, resulting in vomiting.  
  • Feeling lightheaded or dizzy. 

Causes  

Gastritis refers to the inflammation of the lining of the stomach. When the protective mucuslined barrier that shields the stomach wall is weakened or damaged, digestive juices can harm and inflame the stomach lining. Several diseases and conditions, including inflammatory conditions like Crohn’s disease, can elevate the risk of developing gastritis.  

Risk factors  

Your risk of gastritis is affected by the following factors:  

  • Older age. Because the stomach lining thins with age and because older people are more likely than younger people to have autoimmune illnesses or H. pylori infections, older people are at higher risk for developing gastritis.  
  • Bacterial infection. Although Helicobacter pylori infection is one of the most widespread human diseases in the world, only a small percentage of those infected go on to develop gastritis or other upper gastrointestinal illnesses. Doctors hypothesize that bacterial susceptibility may be inherited or brought on by lifestyle factors like smoking and nutrition.  
  • Stress. Acute gastritis can be brought on by extreme stress brought on by major surgery, trauma, burns, or serious infections.  
  • Regular use of pain relievers. Nonsteroidal antiinflammatory medicines (NSAIDS), sometimes known as painkillers like ibuprofen and naproxen sodium, can lead to both acute and chronic gastritis. Regular use of these painkillers or excessive dosages of these medications may cause a reduction in a crucial compound that protects the stomach’s protective lining.  
  • Excessive alcohol use. Your stomach’s lining might become inflamed and eroded by alcohol, making it more susceptible to digestive fluids. Acute gastritis is more prone to develop in people who drink excessively.  
  • Cancer treatment. Your risk of gastritis may increase if you are receiving chemotherapy medications or radiation therapy.  
  • Autoimmune gastritis. Autoimmune gastritis happens when your immune system attacks the cells in your stomach lining, which can weaken the stomach’s protection. This type is more common if you have other immunerelated issues like Hashimoto’s disease or type 1 diabetes. It’s also connected to low vitamin B12 levels.
  • Other diseases and conditions. Other medical problems like HIV/AIDS, Crohn’s disease, celiac disease, sarcoidosis, and parasite infections can all be linked to gastroenteritis.

Diagnosis   

While your physician will likely consider gastritis based on your medical history and physical examination, they might recommend additional tests to accurately identify the underlying cause. There are some potential diagnostic procedures: 

  • Tests for H. pylori: To determine if the bacterium H. pylori is causing your symptoms, your doctor might suggest tests like a stool test or breath test. The breath test involves drinking a clear liquid containing radioactive carbon. If you’re infected with H. pylori, your breath sample will show traces of this radioactive carbon. 
  • Endoscopy to examine the upper digestive system: An alternative or additional diagnostic approach is an endoscopy. During this procedure, a flexible tube with a camera (endoscope) is inserted through your throat into your esophagus, stomach, and small intestine. This allows your doctor to visually examine these areas for signs of inflammation or abnormalities. Biopsies can also be taken if any suspicious areas are detected. These biopsies can reveal the presence of H. pylori in your stomach lining. 
  • Upper digestive system Xray: Referred to as a barium swallow or upper gastrointestinal series, this sequence of Xray scans generates visuals of your esophagus, stomach, and small intestine, with the aim of detecting any abnormalities. To enhance visibility and improve the detection of ulcers, you might ingest a white, metallic liquid (containing barium) that coats your digestive system. 

Treatment  

The treatment of gastritis depends on its underlying cause. For example, acute gastritis caused by the use of nonsteroidal antiinflammatory drugs or alcohol can often be relieved by discontinuing the consumption of those substances. 

Medications used to treat gastritis include: 

  • Antibiotics: In situations where H. pylori infection is present in the digestive tract, a combination of antibiotics is often prescribed. This regimen could involve antibiotics like clarithromycin and amoxicillin or metronidazole to eliminate the bacterium. It’s crucial to complete the full antibiotic course, typically spanning 7 to 14 days, alongside medications that inhibit acid production. Following treatment, a retest is usually conducted to ensure successful eradication of H. pylori. 
  • Acid Production and Healing Aids: Proton pump inhibitors (PPIs) are medications that diminish acid production by inhibiting specific cellular components responsible for acid generation. These drugs include omeprazole, lansoprazole, rabeprazole, pantoprazole, and others. Prolonged use of highdose PPIs may potentially elevate the risk of fractures in the hip, wrist, and spine. Consult your doctor about the potential benefits of a calcium supplement in mitigating this risk. 
  • Acid Production Reducers: Acid blockers, also known as histamine (H2) blockers, are prescribed to decrease the quantity of acid released into the digestive tract. This alleviates gastritisrelated discomfort and promotes healing. Acid blockers like famotidine, cimetidine, and nizatidine are available both overthecounter and by prescription.
  • Stomach Acid Neutralizers: Doctors might incorporate antacids into the medication regimen. Antacids work by neutralizing existing stomach acid, providing rapid pain relief. Potential side effects include constipation or diarrhea, contingent on the ingredients. While antacids offer immediate symptom relief, they are generally not utilized as the primary treatment method. Proton pump inhibitors and acid blockers are more efficacious and tend to have fewer side effects.

Doctors who treat this condition