Chronic myelogenous leukemia (CML) is rare form of cancer that occurs in the bone marrow. Bone marrow is a tissue that has texture of a sponge located inside the bones where blood cells are produced. The development of CML results in an increased number of white blood cells in the blood.
CML is a type of disease that develops gradually. The disease impacts on elders and rarely occurs in children. The advancement of treatments has a high chance for patients with chronic myelogenous leukemia to recover. Majority of the patients have more prospective for remission and prolonged life after being diagnosed.
Chronic myelogenous leukemia is also known as chronic myeloid leukemia and chronic granulocytic leukemia.
Chronic myelogenous leukemia is usually asymptomatic. The disease could be found during a blood test. Once it has been detected, the following symptoms may occur:
Chronic myelogenous leukemia develops when there is a malfunction of genes of bone marrow cells.
When chronic myelogenous leukemia occurs the BCR-ABL gene results in the tyrosine kinase that enables the growth of excessive number of white blood cells. The abnormal Philadelphia chromosome exists in almost of the cells. Unlike normal cells, white blood cells that are diseased are not produced and die. They accumulate by in mass and decrease the growth of healthy blood cells, destroying the bone marrow.
Having a family history of chronic myelogenous leukemia is not considered as a risk factor. The mutations that results in the development of the disease are not passed genetically. The mutation occurs after the child has born.
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