Common Variable Immunodeficiency (CVID)


When signs of an immune disorder or uncommon reactions to vaccines arise, doctors may consider CVID as a potential explanation. To investigate, the doctor will: 

  • Inquire about family medical history. 
  • Conduct blood tests: These tests can reveal CVID indicators, such as low IgG levels. Furthermore, they aid in evaluating the immune system’s efficiency. 

In addition, the doctor could administer an alternative vaccine to observe the body’s response, facilitating further assessment.


CVID has no cure. However, continuous treatment may help individuals manage the condition and are able to lead active lives. Common treatments for CVID include: 

  • Immunoglobulin (IgG) replacement therapy: People requiring IgG therapy receive it continuously in order to prevent infections. This treatment involves replacing the deficient immunoglobulin with antibodies sourced from a group of healthy donors’ blood. The administration of this treatment is either intravenous (through a needle inserted into the vein) or through an injection beneath the skin (subcutaneous).
  • Antibiotics: These are used to treat infections associated with CVID.